The two sides meet at the Tottenham Hotspur Stadium on Tuesday in a replay of their FA Cup third round tie.
Paulo Gazzaniga starts in goal, behind a back four of Japhet Tanganga, Davinson Sánchez, Jan Vertonghen and Ryan Sessegnon.
Eric Dier parters Harry Winks and Giovani Lo Celso in midfield.
Christian Eriksen and Erik Lamela will play just off lone frontman Lucas.