The super Sunday of Premier League action kicks off in the capital as West Ham take on Tottenham Hotspur.
The visitors ring in the changes from their comfortable midweek Europa League victory over Wolfsberger.
Dele Alli, Gareth Bale, Harry Winks and Matt Doherty all make way, with Japhet Tanganga handed a start in the right-back position.
For the Hammers, Michail Antonio returns to the starting line-up after missing out recently with fatigue.
Spurs will be aiming for a big win after losing four of their last five league games.