Best Bets and Sportsbook Picks for MLS Matchday 6 | OneFootball

Thanks for checking out my weekly article for MLS Week 6 bets. With an increasing amount of AI generated trash, I wanted to add authentic human-written articles each week into the MLS gambling space.

In addition to weekly Sportsbook articles, my show The Designated Pundits goes live every Monday at 8:30 PM ET with weekly recap shows and 8:00 PM ET with weekly predictions shows.

We give bets for each matchday; here are our results on the season.

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Match- New England Revs host RBNY

This weekend the New England Revolution will host the New York Red Bulls, and I am looking at a game script parlay. I think the Red Bulls are the far superior team, as their 2-2-1 record and +2 goal differential would tell. In comparison, the Revolution have 1 draw and 3 losses with a -4 goal differential.  Their only goal yet this season is an own goal; they have no scoring players in 2025.

The New England Revolution are coming off of a bye week, which I don’t think will help or hurt their squad.  They haven’t yet solidified any team chemistry yet this season, and will most likely be without Leonardo Compana, their only real scoring threat.

Pick- Red Bull DC & U3.5 Goals -121

The New York Red Bulls proved a tough defense through the 2024 playoffs, and are currently tied with 4 teams that only conceded 4 goals in 2025.  While the Revolution are bad, they are also not conceding. I love the under at 2.5, but to further mitigate risk I’m taking the alternate under on 3.5 goals as my first piece.

I am pairing the under of 3.5 goals with any Red Bull result.  Historically, they are poor in Gillette Stadium and poor against the Revs.  I like that the double chance on Red Bulls to win or draw has protection against the 0-0 possibility.  My first official bet for MLS week 6 is Red Bulls DC & U3.5 Goals at -121.

Match- Toronto FC host the Vancouver Whitecaps

This weekend we will have a Canadian clash as Toronto FC take on the Vancouver Whitecaps.  These two sides couldn’t have had a more different start to the season.  Vancouver came out of the gate hot with 4 wins before dropping their first loss last week against Chicago.  Toronto FC, however, started with a draw and have since accumulated 4 losses.

This is a simple “good team vs bad team” handicap, where I love the plus money you’re getting on Vancouver.  As I write this article late Wednesday, the Whitecaps are +135, which stands as my second play of the week.

Pick- Vancouver Whitecaps +135

Toronto FC have allowed at least 2 goals in all 5 of their 2025 matches.  In fact, their 12 goals allowed give them an average of 2.4 goals allowed per match.  These are both “worst in MLS” stats, and will be exploited by the Whitecaps, who scored 10 goals, the most in the Western Conference.

If you are interested, you can probably also find a nice price on Brian White as an anytime goal scorer.  Without Gauld, White is the lead dog, and should pay out in the ballpark of +155 should he find the back of the net.

Match- FC Dallas hosts Sporting KC

FC Dallas will host Sporting KC this weekend in what could be a sneaky close match.  FC Dallas are looking for their first home win after falling to the Chicago Fire and Vancouver Whitecaps.  How much of that is on Dallas versus how much of that is on Chicago or Vancouver is yet to be decided.  I personally think those losses are less a reflection of Dallas and more a reflection of Chicago and Vancouver having a great start.

Sporting KC, on the other hand, have been nothing but poor.  They have a draw and four losses in 2025, and already crashed out of the CONCACAF Champions Cup after two straight losses to Inter Miami. That puts them at 0-1-6 since February 25th.

Pick- FC Dallas -120

Since accepting that not every wager needs to be a plus-odds bomb, my results have drastically improved.  That is what I’m doing here; I’m taking the home team, FC Dallas at -120 as an official MLS week 6 bet.

I think they have this game circled on their calendar as a “get right” affair.  After all, they were a very solid 10-2-5 at home in 2024.  I think they get back to their winning ways, possibly a that hands of Petar Musa or Luciano Acosta, the latter of which scored in Dallas’s 2-1 win over RSL last weekend.

Match- LA Galaxy host Orlando City

The LA Galaxy have been a bit puzzling and a bit unpredictable this season.  Without Riqui Puig or Jeremy Paintsil, their offense is not as high powered as we had expected.  They have scored only 4 goals while allowing 10, and are winless with a 0-2-3 start.

Orlando City, on the other hand, are sitting at 2-1-2 with 13 goals scored (the most in MLS) and 11 conceded (the second most in MLS).  That means they are averaging 4.8 total goals in each match to start 2025. That is a huge number, and one that gives me faith that even the LA Galaxy can produce a few goals this weekend.

Pick- BTTS & Over 2.5 Goals

Last week I said that we need to be attacking Orlando City’s defense every chance we get.  I chose BTTS and O2.5 Goals last week at -125, so of COURSE I am taking the same bet this week at -112.

The tricky part here is both teams scoring, but if recent history is any indication, then Orlando’s defensive ineptitude and offensive prowess should carry the day. MLS week 6 has some nice plays, and I think finishing the week with a high scoring game solidifies our card.